(c) Heat map of the hair shaft length from the four different treatment methods ( m-ESD, MNX, VD 3, and NS) as a function of time. (b) H&E staining of the epidermis under different treatment methods and time (scale bar = 200 μm). (a) Comparison of hair regeneration under the influence of m-ESD, Minoxidil (MNX), vitamin D 3 (VD 3), and normal saline (NS) top: as-shaved rat bottom: after 3-week treatment. Hair regeneration effect of SD rats under different treatment methods. Growth factors hair regeneration motion-activated device physical approach rats and nude mice. This work provides an effective hair regeneration strategy in the context of a nonpharmacological self-powered wearable electronic device. The device can also improve the secretion of vascular endothelial growth factor and keratinocyte growth factor and thereby alleviate hair keratin disorder, increase the number of hair follicles, and promote hair regeneration on genetically defective nude mice. Higher hair follicle density and longer hair shaft length were observed on Sprague-Dawley rats when the device was employed compared to conventional pharmacological treatments. Significantly facilitated hair regeneration results were obtained from Sprague-Dawley rats and nude mice. Here, a universal motion-activated and wearable electric stimulation device that can effectively promote hair regeneration via random body motions was designed. As a nonpharmacological physical approach, physiologically appropriate alternating electric field plays a key role in the field of regenerative tissue engineering. Various pharmacological and nonpharmacological treatments have been widely studied to achieve the desired effect for hair regeneration. Hair loss, a common and distressing symptom, has been plaguing humans.
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